The strike took place yesterday near the western city of Fallujah, destroying "a remotely piloted aircraft" and a vehicle with the IS forces, according to a statement from the US military command overseeing the campaign against the group.
The drone, used for battlefield surveillance, was "small-scale" and not a sophisticated aircraft equivalent to some US-made robotic planes that can fly at high altitudes or launch missiles, US defense officials said.
The United States relies heavily on its own fleet of drones for air operations in Iraq and Syria, using them to bomb targets as well as provide intelligence on IS movements on the ground.
The Syrian regime said yesterday it had shot down an American drone near the coastal province of Latakia and Pentagon officials acknowledged that a robotic aircraft had lost contact in the area.
The air strike on the IS drone was among 11 carried out by US-led aircraft in Iraq and two conducted in Syria on yesterday and today morning.