The political upheavals in Washington DC and Rome have been the main focus in the financial markets this week. While the gridlock in the US capital was showing few signs of resolution on the second day of the partial shutdown, the developments in Italy pointed to a crisis averted.
"Investors are having a little rethink over the implications and longevity of the US government shutdown," said Andrew Wilkinson, chief economic strategist at Miller Tabak & Co.
In the US, the Dow Jones industrial average was down 0.8 per cent at 15,066 while the broader S&P 500 index fell 0.7 per cent at 1,683.
One market that bucked the trend for most of the day was Italy's FTSE MIB, which briefly hit a two-year high.
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The gains came after Silvio Berlusconi threw his support behind the government of Premier Enrico Letta in a confidence vote, acknowledging defeat on the Senate floor after defections in his party robbed him of the backing he needed to bring down the government.
Milan's FTSE MIB was up 0.2 per cent at 18,028. Earlier, it had traded at a two-year high of 18,340, before mounting concerns over the US budget gridlock dented sentiment.
Although most analysts said they expect the US budget stalemate to be resolved before the shutdown inflicts damage on the US economy, the latest stalemate has raised concerns over whether Congress will be able to increase the country's debt ceiling later this month. If it doesn't, the US would face a potential default, a development that could inflict massive damage on the global economy.