The US tycoon regularly bashed China during last year's presidential election campaign, accusing it of unfair trade practices, stealing US jobs and threatening to label it a currency manipulator.
But since taking office his tone has changed and when he met Xi in April he described him as a "good man" who was trying to help rein in North Korea.
Now, the president is set to make his first visit to China as part of a tour that will also take in regional allies Japan and South Korea, with trade one of the top agenda items.
"What makes me really optimistic is the good relationship that has developed between the two."
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"As for the outcomes of the meeting, the most important thing would be deliverables, specific things, bigger things... that will help to reduce the trade deficit that the US has with China."
Ross described the relationship between the world's two biggest economies as "too lopsided at present", with US trade deficit reaching nearly $350 billion last year.
US Secretary of State Rex Tillerson will be travelling to China tomorrow for talks on how to defuse the nuclear stand- off with North Korea.
Washington has alternated between criticising and praising Beijing's role in the North Korea crisis, on the one hand welcoming its support for new sanctions but also insisting it must do more to rein in its unruly neighbour.
"We've been trying to go step-by-step gradually increasing the economic pressure on North Korea," Ross said.
"If need be and if nothing else happens in terms of other alternative solutions, you can bet the US will increase the pressure as best it can.