The Pentagon says a Saudi national known as Sanafi al-Nasr was "a longtime jihadist experienced in funneling money and fighters" for the terrorist network.
A statement from the US Defense Department says coalition forces conducted the airstrike on Thursday over northwest Syria.
The US says he was a leading figure in the Khorasan group, a secretive cell of al-Qaida operatives who US officials say were sent from Pakistan to Syria to plot attacks against the West.
US Defense Secretary Ash Carter says the military operation "deals a significant operation" to the Khorasan group's plans to attack the US and its allies.