The CIA-operated spy plane attacked a hideout of the Pakistani Taliban in Mangroti area of North Waziristan, a senior security official said.
"Five militants were killed and several others injured in the attack," he said.
He said one of those killed was identified as Noor Saeed who was commander of outlawed Tehreek-e-Taliban Pakistan.
The death toll could not be verified through independent sources as the area is out of reach for the news media. It was the first strike of 2016 after at least 13 drone attacks last year.