The pilotless aircraft attacked a compound in Alwara Mandi area near Datta Khel town.
A security official said that 10 militants were killed.
The identity of those killed was not known immediately.
Drone strikes in the country resumed in June after a gap of six months when two successive drone strikes on June 11 reportedly killed around 16 people in Miranshah.
A similar drone strike in the Datta Khel area on August 6 left six people dead.
Pakistan launched operation in North Waziristan in June 15, killing more than 1,000 militants.