The CIA-operated unmanned plane fired four missiles targeting the compound and the vehicle in Danday Darpakhel area in North Waziristan tribal region's Miranshah last night.
"So far the reports show that around 18 people have been killed in the incident," a security official.
The identity of those killed was immediately not known but the militants linked with al-Qaeda are active in the area.
This was the second drone attack in two months.
Pakistan opposes the drone attacks, saying civilians are killed in the strikes, but US maintains it target militants.
The fresh strike may create tension between the US and the government of Prime Minister Nawaz Sharif, who promised in his election campaign to stop the unilateral drone attacks.