The CIA-operated drone fired two missiles at a time, targeting a motorcycle and a compound in village Dawar Musaki tehsil Mir Ali in North Waziristan Agency, sources said.
The strike killed two people, they said, adding that it took place after at 11 pm.
In the month of Ramadan, this was the first attack in North Waziristan.
The identity of those targeted in the strike could not be ascertained.