The drone destroyed two vehicles in the town of Nasab and killed seven members of Al-Qaeda in the Arabian Peninsula, the sources said.
"The shell left the cars and the militants inside in pieces," one said.
Today's raid is the fifth of its kind since July 28 and brings to 24 the number of suspects killed since then.
The United States and its allies pulled diplomats out of Yemen on Tuesday and stepped up security at missions across the Middle East.
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While the closures span cities across the Arab world, the focus of concern has been Yemen, where American forces are fighting a drone war against Al-Qaeda's powerful regional affiliate.
According to media reports, the trigger for the pullback came when US intelligence intercepted messages between Zawahiri and Nasir al-Wuhayshi, the leader of Al-Qaeda's Yemen offshoot, Al-Qaeda in the Arabian Peninsula (AQAP).
The New York Times said Monday that last week's electronic communications revealed Zawahiri had ordered AQAP to carry out an attack as early as last Sunday.
The Yemen-based group has attempted several attacks on the United States, including a failed bid to bring down a passenger plane by a man wearing explosives in his underwear and another to send bombs concealed in printer cartridges.
United States has launched scores of drone strikes in Yemen, where the militant group thrives in vast, lawless areas largely outside the government's control.
Yemen has listed the names of 25 Al-Qaeda suspects wanted in connection with an alleged plot to launch a major attack before Ramadan ends and the Eid al-Fitr feast begins tomorrow.