The CIA-operated drone, in a pre-dawn attack, struck militant hideouts in the Shahidano Dhand area of Lower Kurram Agency.
A security official said three hideouts as well as two vehicles parked there were destroyed.
"One militant was also injured in the attack," he said.
Another official said the injured rebel was part of Haqqani network which is major supporter of Taliban and had been involved in lethal attacks.
Pakistan is opposed to US drone attacks and considers it a violation of its sovereignty.