The attack came in North Waziristan, where for the past month the Pakistani military has been fighting to wipe out longstanding bases of Taliban and other militants.
"The drone fired eight missiles on the compound around 0230 IST on Saturday killing eleven members of the Punjabi faction of the Pakistani Taliban," a senior security official in the region said.
The official said the dead included two "important" commanders of the Pakistani Taliban, but he refused to reveal their identities. An official had earlier given a lower death toll of eight militants dead.
Pakistan's semi-autonomous tribal areas on the Afghan border have for years been a hideout for Islamist militants of all stripes -- including Al-Qaeda and the homegrown Tehreek-e-Taliban Pakistan (TTP) as well as foreign fighters such as Uzbeks and Uighurs.
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Washington pressed Islamabad for years to take action to wipe out sanctuaries in North Waziristan, which militants have used to launch attacks on NATO forces in neighbouring Afghanistan.
Jets and artillery began hitting rebel targets in mid June to try to regain full control of the district and ground forces moved in on June 30.
The assault by Pakistan's military was launched after a dramatic attack by militants on Karachi airport which killed dozens of people and marked the end of a faltering peace process with the Pakistani Taliban.
More than 400 militants and 25 soldiers have been killed in the assault so far, according to the military, though the area is off-limits to journalists, making it impossible to verify the number and identity the dead independently.