The US Africa Command tells The Associated Press that the strike occurred Monday about 35 miles southwest of the capital, Mogadishu. The US says it is still assessing the results.
Saturday's truck bombing in Mogadishu killed more than 300 people and wounded nearly 400 others.
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The US has carried out several drone strikes in the Horn of Africa nation since President Donald Trump approved expanded military operations against the group this year.
Al-Shabab has not commented on the truck bombing, which Somali intelligence officials say was meant to target Mogadishu's heavily fortified international airport. Several countries have embassies there.
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