The drone targeted a house and a car early in the morning, security sources said.
"At least 8 people were killed in a drone strike near Pak-Afghan border in Datta Khel area of North Waziristan," the sources were quoted by The Nation newspaper as saying.
It was the second drone strike in 24 hours. Another strike on late Sunday killed at least five people.
It is the fourth drone strike to hit the tribal area after the army launched an operation against militants in the area in June.
For almost a decade, American drone strikes in Pakistan's tribal belt have been deeply unpopular with the public.
Pakistani officials have publicly condemned the drone strikes saying they violate sovereignty.