Most of them arrived illegally but were allowed to remain under Temporary Protected Status (TPS), which applies to migrants from several countries around the world.
The decision to end TPS for Nicaragua on January 5, 2019, announced yesterday, comes as President Donald Trump's administration tries on many fronts to restrict the flow of immigrants and refugees.
Acting Secretary of Homeland Security Elaine Duke said the end date would provide for "an orderly transition."
The migrants were initially granted protected status in the US after Hurricane Mitch slammed Central America in 1998, with renewals granted following other natural disasters.
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Most of the TPS migrants arrived in the United States without legal papers but were allowed to stay and work because of instability in their home countries.
Duke determined that "those substantial but temporary conditions caused in Nicaragua by Hurricane Mitch no longer exist", meaning the TPS must end.
About 50,000 Haitians in the United States are also covered by the program, after receiving TPS status following the 2010 earthquake that devastated the impoverished Caribbean nation.
The largest group of TPS recipients are from El Salvador, The Washington Post has reported.