The 11th round of discussions, to be held in Miami, will address a still substantial list of differences on key issues between the two sides, after more than two years of talks on the ambitious Transatlantic Trade and Investment Partnership.
But they come after Washington scored a major triumph with
the agreement two weeks ago to set up a Pacific free trade group with Japan, Canada and nine other countries.
Both groupings aim at broadly lowering trade tariffs and non-tariff barriers, a relatively small issue between the United States and Europe, where trade taxes are already very low.
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A deal would tie together two giant economies that are home to some 850 million people and account for about half of global output.
But the success of the Trans-Pacific Partnership Talks will not necessarily make the hefty task of getting Americans and Europeans to agree on a similar project any easier.
Supporters say a transatlantic trade deal will give a strong boost to economic growth and job creation.
Showing that the opposition has not weakened, the "Stop TRIP" movement has collected three million signatures in support of its effort to halt the negotiations.
It drew as many as 250,000 people to an anti-TRIP protest in Berlin on October 10.
Politicians on both sides are also expressing misgivings, especially around the intense secrecy of the negotiations, with a top French official recently lashing out at Washington's stance.