The sanctions' targets include Abu Sulayman al-Adani, identified as the overall leader of the growing Islamic State operation in Yemen.
It also included the IS group's alleged assassinations chief, Radwan Muhammad Husayn Ali Qanan, and its main financier, Sayf Abdulrab Salem al-Hayashi, who owns a chain of supermarkets.
The move aims to freeze the assets across the Gulf and in US jurisdiction of 11 individuals and two entities which the countries say are key to the Yemen operations of the Islamic State group and Al-Qaeda in the Arabian Peninsula.
"We coordinated this action with the Kingdom of Saudi Arabia, the United Arab Emirates, Kuwait, Oman, Bahrain, and Qatar, who designated these advocates of terror under their own domestic authorities. This is the largest ever multilateral designation in the Middle East."
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The TFTC was announced on May 21 as a joint effort to pursue the financial resources of officially designated "terror" groups across the region.
Speaking on condition of anonymity, Trump administration officials told journalists the announcement Wednesday was well choreographed in advance between banks, central banks, the finance industries, and the intelligence services of the US and the six Gulf countries.
"We went after every asset they have in the Gulf simultaneously this morning," one official said.
He would not describe, however, any of the assets seized.
The official said that TFTC cooperation was strong despite the broader political dispute between Qatar and the other five Gulf states involved.
"That's not a minor thing.