The three -- Shradha Agarwal from Chicago, Riddhiman Das from Kansas and Amar Sawhney from Massachusetts -- were presented with the award at the White House.
They were among 11 people honoured yesterday.
The Indian-Americans and others were felicitated at the "Champions of Change" event at the White House that highlighted immigrant innovators and entrepreneurs - the best and brightest from around the world who are helping create American jobs, grow the economy, and make the US more competitive, an official statement said.
"We are proud to recognise these leaders who work every day to grow our economy, advance science and technology, and support their home communities," Park said.
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The Champions of Change programme was created as an opportunity for the White House to feature groups of Americans - individuals, businesses and organisations - who are doing extraordinary things to empower and inspire members of their communities.
Shradha Agarwal from Chicago is co-founder of ContextMedia and she always had a passion for communication and launched her first media enterprise at age nine in India.
Based in Chicago and New York City, Agarwal is also an angel investor, conference speaker and startup advisor.
Riddhiman Das from Kansas came to the United States in 2008 to pursue an American college education and studied Computer Science, Mathematics and Entrepreneurship.
"As an undergraduate student, he co-founded three startup tech companies and is also heavily involved with a Kansas City-based technology startup that has commercialised the Eyeprint Verification System as a simple, safe replacement for entering passwords on smartphones," the White House said.
"He has founded six companies, which account for over 1,600 jobs created and over USD 1.5 billion in revenue to date. Amar helps foster entrepreneurship by mentoring young innovators and creating companies through Incept, a medical device incubator he helped co-found," the White House said.