The Cleveland Clinic yesterday said that it will be the first hospital in the United States to offer transplanted uteruses to 10 women beginning in the next few months.
The clinical trial is open to women of childbearing age who are unable to become pregnant "because they were born without a uterus, have lost their uterus, or have a uterus that no longer functions," said a hospital statement.
The transplants will come from deceased donors and will be temporary. Each organ will removed after the recipient is able to bear one or two children.
"To date, the Swedish group has performed nine uterus transplants, achieving five pregnancies and four live births," the Cleveland Clinic said.
More From This Section
The road has been long, however, and the first two international attempts at uterus transplants in Saudi Arabia and Turkey were unsuccessful.
Organ rejection during pregnancy has been a key problem.
"The exciting work from the investigators in Sweden demonstrated that uterine transplantation can result in the successful delivery of healthy infants," said Cleveland Clinic lead investigator Andreas Tzakis.
The approach "is still considered highly experimental," said Tommaso Falcone, an obstetrician and chair of the Cleveland Clinic Women's Health Institute.
Infertility due to uterine problems affects thousands of women around the world, and until now few options have existed other than surrogacy or adoption.
The hospital has already begun screening potential candidates, ranging in age from 21 to 39.
Women accepted into the study face rigorous medical and psychological evaluations, and must agree to have her eggs retrieved, then fertilised and the embryos frozen until they are ready for transplantation.
"One year after transplant, the frozen embryos are then thawed and implanted, one at a time, into the patient until she becomes pregnant," said the hospital.