The bill, passed yesterday with a overwhelming 400-20 votes by the House of Representatives, would slap strict limits on Iran's already heavily-sanctioned oil industry, as well as on other sectors of the country's ailing economy, including the automobile and mining sectors.
The move is also aimed at crippling Iran's oil industry, considered as the lifeline of the country's economy.
The West accuses Iran of covertly developing nuclear weapons. However, Tehran denies the charge and maintains that its nuclear programme is for peaceful purpose.
Rouhani will assume office on Sunday.
More From This Section
The bill blacklists any business in Iran's mining and construction sectors and commits the United States to the goal of ending all Iranian oil sales worldwide by 2015.
The bill builds on US penalties that went into effect last year that have cut Iran's petroleum exports in half and hurt its economy.
Still, China, India and several other Asian nations continue to buy billions of dollars of Iranian oil each month.
Despite plummeting sales overseas, Iran remains one of the world's largest oil producers. Its exports bring in tens of billions of dollars in revenue for the country.