"I believe we have done a great deal, since the financial crisis, to strengthen the financial system and to make it more resilient," Yellen told members of the Senate Finance Committee during a Congressional hearing.
The 70-year-old US economist was responding to a question on American financial institutions' readiness on facing next economic crisis.
"I think we can never be confident that there won't be another financial crisis. But we have acted, in the aftermath of that crisis, to put in place much stronger capital and liquidity requirements for systemic banking organisations and the banking system more generally," Yellen said.
"It's giving us assurance that, even if there is this very significant downturn in the economy - that they will be able to function and provide for the credit needs of the economy. We have greatly increased our monitoring of the financial system for a broader range of risks," she said in response to a question from Senator Sherrod Brown.
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Yellen said it was important that the US maintains the improvements that have been put in place that mitigate the risk and the potential damage.
"With respect to the global economy, we've been through a period in which there's been a substantial appreciation of the dollar, and that depressed, for quite some time, import prices. But that trend has now come to an end, and import prices are rising in a modest rate," she said.
"I do think there are some special one-time transitory factors, these unusual changes reflecting the move to unlimited data plans for cell phones and large declines in some prescription drug prices. There may be more going on, and we're watching inflation very carefully in light of low readings," Yellen said.