The Sensex, which had gained 58.25 points in the previous three sessions, fell by 92.77 points, or 0.42 per cent to 21,740.09 -- the weakest closing since 21,513.87 on March 6.
Intra-day, it touched a low of 21,704.66 and a high of 21,853.25. In the 30-share BSE index, 22 stocks led by HDFC and L&T closed in the red. Aided by value-buying after recent weakness, TCS and Infosys led the eight Sensex gainers today.
US Federal Reserve chair Janet Yellen's comments after the Fed's first policy meeting sent ripples through global markets. At a press conference last night, reports said, Yellen implied Fed's time-frame for raising rates was closer to first half of 2015, sooner than expectations.
The Fed also voted to cut its monthly bond purchases from USD 65 billion to USD 55 billion.
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In Asia, all major equity indices were sharply down. Prominent European indices were trading about one per cent lower each in early trades.
The rupee also weakened to 61.4 levels against dollar.
"Post US Federal Reserve statement indicating that further tapering of monetary stimulus package shall continue and interest rates may also be increased in near future, market sentiment was poor...Metal stocks were also showing weakness on concerns over slowing demand in China," said Nidhi Saraswat, Senior Research Analyst, Bonanza Portfolio.
Bucking the general trend, Tata Consultancy Services, Infosys and Wipro rose. TCS had led the fall in IT pack stocks yesterday on revenue growth concerns. The BSE-IT index today gained 1.69 per cent.