"Due to information about a possible security threat against the US Consulate General in Istanbul, the Consulate will open with limited staff and services" today, the mission said in a statement.
It said public services, including visa appointments and non-emergency services for American citizens scheduled for Wednesday had been "cancelled and will be rescheduled for a later date."
The move comes after the US authorities warned on December 5 of an "imminent security threat against the US consulate compound" in Turkey's largest city.
Istanbul is on high alert for attacks following three deadly bombings blamed on the Islamic State (IS) group in Ankara and the southeast of the country this year.
But there have also been attacks on security forces by the outlawed Kurdistan Workers Party (PKK) and sporadic actions by the the banned ultra-left wing group the Revolutionary People's Liberation Party-Front.