"The critical question is this: Should a special-interest organisation like National Rifle Association (NRA) have veto power over the appointment of the nation's top doctor? The very idea is unacceptable," the New England Medical Journal said in its latest issue that hit the stands yesterday.
Boston-based Murthy, 36, if confirmed by the US Senate, would be the first Indian-American and the youngest ever to occupy the top position.
The gun lobby led by the NRA has been opposing Murthy's nomination, who supported Obama's move against gun-culture in the US.
"It is of great concern to us and to many other members of the healthcare community that Murthy's nomination is in jeopardy because of NRA opposition," the journal said.
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Murthy has already said in his testimony before the Senate HELP Committee that if confirmed, his principal focus will be on the national problem of obesity prevention not firearm policy, it said.
"Still, 10 Senate Democrats are apparently prepared to vote against Murthy's confirmation because of his personal views on firearms - a demonstration of just how much political power our legislators have ceded to the NRA.
"With the record of past surgeons general as their guide, senators should do what is right for the health of the country by confronting the NRA and voting their own conscience. Murthy is an accomplished physician, policymaker, leader and entrepreneur. He deserves the President's continued backing and should be confirmed," it said.
Murthy, whose parents immigrated to the US from India, has lived the American dream, the journal said.