Eleven of the bombings in the heavy barrage targeted IS units, buildings, positions and vehicles near the strategic Mosul Dam, US Central Command, which is overseeing the air war against the jihadists, said in a statement.
The IS militants briefly held Mosul dam in August, but Kurdish forces and Iraqi army troops -- backed up by US air strikes -- succeeded in retaking the dam later that month.
The large dam in northern Iraq is a crucial piece of infrastructure and IS has repeatedly tried to seize it back.
A further four strikes hit near Fallujah, while others targeted Bayji, Qurayat al Hajjaj and other locations in Iraq.
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The sole strike in Syria, near Kobane, destroyed an artillery piece, Centcom said, and was conducted by US aircraft.
"The destruction of ISIL targets in Syria and Iraq further limits the terrorist group's ability to project power and conduct operations," Centcom said.