The evacuees were allowed to relocate under a deal brokered by the Lebanon's Hezbollah militant group that has angered Iraq and the coalition.
Syrian opposition activists say dozens of IS fighters and their families have crossed into areas controlled by the extremists despite U.S. Threats to bomb the convoy.
The coalition said today it will continue to monitor the convoy but not allow it to link up with IS fighters in eastern Syria and western Iraq. It said the coalition will continue take action against IS without harming civilians.