Marquez, who has captained his team a record four times in the World Cup, was one of 22 people and 43 entities the US Treasury placed on a sanctions list in relation to a Guadalajara-based drug trafficking group controlled by businessman Raul Flores Hernandez.
The Treasury yesterday said Marquez has a "longstanding relationship" with Flores, has acted as a "front person" for him and held assets on his drug cartel's behalf.
"Raul Flores Hernandez has operated for decades because of his longstanding relationships with other drug cartels and his use of financial front persons to mask his investments of illegal drug proceeds," said John Smith, head of the Treasury's Office of Foreign Assets Control which implements sanctions.
Also named on the blacklist yesterday under Washington's "Kingpin Act" were Flores and members of his family, business associates, and Latin Grammy-nominated singer Julion Alvarez.
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Mexican authorities meanwhile took actions yesterday to seize assets linked to the group inside the country. US authorities said Flores controls a casino, restaurants, bars, a shipping company and a music production company, mostly based in Jalisco state.
The US announcement rocked the Mexican football world where Marquez, popularly known as Rafa, is a legend at 38 after making his debut for the national team in February 1997 and then leading the team in the last four World Cups.
After that he spent two years with the Red Bulls of US Major League Soccer, and then joined Mexico's Club Leon, and most recently played for Atlas again.
Still potent, he scored the winning goal at the 89th minute in a 2-1 World Cup qualifier victory over the United States last November.
The US statement gave no details on his alleged actions on behalf of Flores. But also blacklisted were Mauricio Heredia Horner, the chief executive of Marquez's charity foundation, according to its Facebook page. In addition, a mariachi singer, Marco Fregoso, was also on the sanctions list as someone who had acted on behalf of Marquez for the Flores organization.
Singer Alvarez, a star of the popular norteoo style of music, said in a televised statement that there was nothing to the reports.
He added that he was "great friends" with Marquez. "Would you believe that he needs to do such things?" he said.