The man bought 25 tickets with the same numbers from Zhou Grocery on South Queen Street in York more than a year ago, but never claimed the prize.
The tickets have now expired and the winnings will go unclaimed.
The man was pretty upset, the York Daily Record reported.
"Wouldn't you be," Wendy Hinton, who works at the store was quoted as saying by the daily.
She sold 25 tickets in March last year to one of her regular customers.
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Shortly after the drawing, she said, the man checked the numbers, but must have misread them and threw the tickets in the trash.
The 25 tickets were worth USD 50,000 each - USD 1.25 million total.
"He was mad," Hinton said of the day he found out that he threw away more than a million dollars."He was so mad he played USD 400 that day."
The USD 1.25 million jackpot will now remain in the state Lottery Fund.