Under the proposal, which is open for public comment for 60 days, the Food and Drug Administration announced its preliminary determination that partially hydrogenated oils, the source of trans fats, were no longer "generally recognised as safe" for use in food.
The FDA's preliminary determination is based on available scientific evidence and the findings of expert scientific panels, the agency said in a statement.
"While consumption of potentially harmful artificial trans fat has declined over the last two decades in the United States, current intake remains a significant public health concern," said FDA Commissioner Margaret Hamburg.
Consumption of trans fat raises low-density lipoprotein (LDL), or bad cholesterol, increasing the risk of coronary heart disease.
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The independent Institute of Medicine (IOM) has concluded that trans fat provides no known health benefit and that there is no safe level of consumption of artificial trans fat. Additionally, the IOM recommends that consumption of trans fat should be as low as possible while consuming a nutritionally adequate diet.
Trans fat can be found in some processed foods, such as certain desserts, microwave popcorn products, frozen pizzas, margarines and coffee creamers.
Since trans fat content information began appearing in the Nutrition Facts label of foods in 2006, trans fat intake among American consumers has declined from 4.6 grams per day in 2003 to about 1 gram per day in 2012.
"One of the FDA's core regulatory functions is ensuring that food, including all substances added to food, is safe," said Michael Taylor, the FDA's deputy commissioner for foods and veterinary medicine.
The FDA's move concluded three decades of battles by public health advocates against artificial trans fats, which occur when liquid oil is treated with hydrogen gas and made solid, the New York Times said.