The Wells Fargo museum is a destination for schoolchildren and tourists and includes two restored stagecoaches, a working telegraph and other California Gold Rush-era memorabilia collected by the bank that got its start in the city.
The thieves rammed a Chevrolet Suburban through the museum's revolving door around 2:30 am Tuesday.
One of them held a security guard at gunpoint while the others took up to 10 ounces of gold nuggets worth an estimated USD 10,000 from a display case.
"Rest assured, the museum will reopen, so it can continue to serve the thousands of visitors and Bay Area residents who visit it each year," Pulido said. Wells Fargo opened its first branch on the site in 1852, he said.
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The tactic mirrored three other smash-and-grab thefts involving vehicles in the San Francisco Bay Area since May.
Police said they are investigating whether there's a connection.
On November 26, two men rammed a vehicle into an upscale designer boutique in Union Square and took handbags.
Across San Francisco Bay, robbers in May busted through the glass at an Apple Store in a bustling shopping district in Berkeley to steal electronics.
Police did not reveal the value of the stolen merchandise in any of the cases.
In yesterday's robbery, the stolen gold was estimated to be worth roughly USD 10,000, but Wells Fargo officials were trying to determine exactly what was taken before settling on a more precise figure.
The robbers may have difficulty selling the nuggets unless they get melted down, he said.
Melting the gold could remove possible markings concerning when and where the nuggets were mined, said Fred Holabird, a mining geologist and an owner of a rare and unique collectibles business in Reno, Nevada.