The discussions involving Deputy Secretary of State William Burns, Undersecretary of State for Political Affairs Wendy Sherman and Jake Sullivan, Vice President Joe Biden's top foreign policy adviser, are set for Monday and Tuesday.
The interim deal reached in November by Iran and six world powers - the US, Russia, China, Britain, France and Germany - limited Iran's uranium enrichment program.
Those nuclear talks are scheduled to resume June 16. There's an informal deadline of July 20 for a comprehensive deal.
Iran's official IRNA news agency said the upcoming US talks would be followed by separate discussions in Rome between Iranian and Russian officials on Tuesday and Wednesday.
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IRNA quoted Abbas Araqchi, a senior member of Iran's nuclear negotiating team, as saying that the Islamic Republic planned to hold other bilateral talks as well with the other world powers, but those meetings had yet to be set.
The new face-to-face talks come as the deadline approaches for world powers and Iran to translate their interim nuclear agreement into a comprehensive deal.
Talks have focused on restricting Iran's uranium enrichment and eliminating the possibility of it producing plutonium that can be used in warheads. In exchange, the US and others would ease penalties that have crimped Iran's economy.
International inspectors would monitor Iran to ensure it doesn't ramp up activities to reach a nuclear weapons capability.
That deal, reached in broad terms in November and implemented in January, provided Iran up to USD 7 billion in eased trading conditions for several nuclear concessions.