US Air Forces Europe spokeswoman Capt Lauren Ott said the remotely piloted aircraft crashed early today. No one was hurt in the incident.
There was no word on what caused the crash and Ott wouldn't comment on the drone's mission.
Incirlik, near the border with Syria, is home to US fighter jets and other aircraft belonging to the anti-Islamic state coalition.
Witness Mehmet Bayram told the state-run Anadolu Agency that he saw an object with flashing lights crash into the field before hearing a large explosion. He said police arrived on the scene, followed by American officials who conducted inspections.