The now-failed final document of a landmark treaty review conference had called on the UN secretary-general to convene the Middle East conference no later than March 2016, regardless of whether Israel and its neighbours agree on an agenda.
Israel is not a party to the Nuclear Non-Proliferation Treaty and has never publicly declared what is widely considered to be an extensive nuclear weapons program. A conference might force Israel to acknowledge it.
That has alarmed countries without nuclear weapons, who are increasingly frustrated by what they see as the slow pace of nuclear-armed countries to disarm. The United States and Russia hold more than 90 per cent of the estimated 16,000 nuclear weapons in the world today.
Amid a growing movement that stresses the humanitarian impact of nuclear weapons, Austria announced that 107 states have now signed a pledge calling for legal measures to ban and eliminate them.
Israel had been furious when the US at the treaty review conference five years ago signed off on a document that called for talks on a Middle East nuclear-free zone by 2012. Those talks never took place.
The language on the final document rejected Friday was "incompatible with our long-standing policies," said Rose Gottemoeller, the US under secretary of state for arms control and international security.