The 46-year-old woman "likely acquired" human immunodeficiency virus while in a monogamous relationship with an HIV-positive female partner in Texas, said the Centers for Disease Control and Prevention.
The woman, whose name was not released, had engaged in heterosexual relationships in the past, but not in the 10 years prior to her HIV infection.
Her HIV-positive partner, a 43-year-old woman who first tested positive in 2008, was her only sexual partner in the six months leading up to the test that came back positive for HIV.
The strain of HIV with which she was infected was a 98 percent genetic match to her partner's, said the CDC in its weekly report.
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Authorities first learned of the case in August 2012 from the Houston Department of Health.
The couple said they had not received any counseling about safe sex practices, and reported that they routinely had sex without barrier methods.
"They described their sexual contact as at times rough to the point of inducing bleeding in either woman," said the CDC report.
The partner who was infected since 2008 had been prescribed antiretroviral drugs in 2009 but stopped taking them in November 2010, and was lost to follow up in January 2011.
The CDC warned that although such cases are rare, "female-to-female transmission is possible because HIV can be found in vaginal fluid and menstrual blood."
People with HIV should be under the care of a doctor and take their prescribed medicines to keep their viral load down and reduce the risk of infecting a partner, the CDC said.