That candid assessment by US Secretary of State Rex Tillerson reflected the former Cold War foes' inability to forge greater cooperation, as President Donald Trump until recently has advocated.
Even the one significant agreement Moscow suggested had been reached to investigate last week's chemical weapons attack in Syria was quickly rejected by Washington.
"There is a low level of trust between our two countries," Tillerson told reporters in Moscow.
But RC Hammond, a senior Tillerson aide, said flatly: "No agreements were reached." And shortly afterward, Russia vetoed a UN Security Council resolution that would have demanded Syrian cooperation on the investigation.
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More than 80 people were killed in what the US has described as a nerve gas attack that Assad's forces undoubtedly carried out.
The news conference came after Putin met Tillerson for the first time since Trump took office. The diplomats know each other well from Tillerson's days as Exxon Mobil CEO. Putin had even honored Tillerson with a friendship award.
Beyond Syria, Russia's alleged meddling in the US presidential election also hovered over what was the first face-to-face encounter between Putin and any Trump administration Cabinet member.
Lavrov blasted US claims that it has "irrefutable evidence" of election interference.
"We have not seen a single fact, or even a hint of facts," he said. "I do not know who saw them. No one showed us anything, no one said anything, although we repeatedly asked to produce the details on which these unfounded accusations lie."
He said working groups would be established to improve US-Russian ties and identify problems. He said the two sides would also discuss disagreements on Syria and how to end the country's six-year civil war.
But such hopes appeared optimistic as the diplomats outlined their sharply diverging views on Syria. Until the chemical attack, the Trump administration had sought to step back from the US position that Assad should leave power. But Tillerson repeated the administration's new belief that "the reign of the Assad family is coming to an end."
And he suggested that possible war crimes charges could be levied against the Syrian leader. Russia has never publicly acknowledged any such attacks by Assad's forces and has tried for the past 18 months to help him expand his authority in Syria.
The civil war is separate from the US-led effort against the Islamic State group in the north of the country. While the most immediate US-Russian dispute concerned culpability for the chemical weapons, broader disagreements over everything from Ukraine to Russia's support for once-fringe candidates in European elections were among other sore points.