The MV Cape Ray was scheduled to leave in the afternoon for what is expected to be a roughly two-week trip to the Italian port of Gioia Tauro, where chemicals will be transferred to the ship.
The chemicals include raw materials for making sarin and mustard gas, and they will be destroyed on board the Cape Ray at sea.
A second shipment of chemical weapons today was loaded onto Danish and Norwegian ships at the port of Latakia in Syria, according to a statement from the UN and the Organisation for the Prohibition of Chemical Weapons. The ships are expected to stay in international waters off Syria waiting for additional loads.
The confirmed use of chemical weapons in the Damascus suburb of Ghouta on August 21, in which the US government said 1,400 people died, prompted a US-Russian agreement to eliminate Syria's chemical weapons by mid-2014.
In a message to the crew today, Defense Secretary Chuck Hagel called the mission historic.