Of 15 air strikes in Syria, 12 were aimed at "degrading and destroying their oil producing, collecting, storage and transportation infrastructure," the US Central Command said in a statement.
The jihadists control a swath of territory straddling northwestern Iraq and eastern Syria, home to most of Syria's main oilfields.
Experts say the jihadists were earning as much as $3 million daily from oil before the coalition began launching strikes on Syria, building on the air war under way against IS in Iraq since August 8.
Another of the five others against oil targets was southeast of Deir Ezzor and damaged a modular refinery.
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Three other strikes in Syria hit two IS fighting positions near Kobane and a military camp in the Raqa province.
In Iraq, five air strikes south and west of Bayji "struck two ISIL units, destroyed one ISIL armed vehicle, an ISIL heavy weapon, an ISIL machine gun position, an ISIL building and three ISIL guard shacks and damaged one ISIL guard shack."