Most of the 1,300 cubic meters of chemical weapons that the Syrian regime handed to the international community were neutralised in 2014 on a US Navy ship, then transformed into waste that was treated in different sites around the world.
The devices now envisioned by the Pentagon will allow for such weapons to be destroyed in situ, according to a statement from DARPA, the Defense Advanced Research Projects Agency, which has awarded contracts to build the prototypes.
Current methods like incineration or hydrolysis - breaking a molecule's bonds though the use of water - require a lot of water and create hazardous waste that requires further processing, it added.
Two companies - SRI International based in Menlo Park, California and Southwest Research Institute in San Antonio, Texas, won the contracts.
Syria agreed to give up its chemical arsenal in 2013 under the terms of an international agreement after outrage over use of such arms in attacks that killed hundreds of civilians.