The warning came weeks after a Hong Kong-flagged ship was seized in South Korea for transferring oil products to another vessel.
The UN - at the urging of the US - has imposed a series of sanctions against North Korea aimed at tightening the economic screws on Pyongyang over its missile and nuclear programme.
At a briefing in Hong Kong today, Sigal P Mandelker, under secretary for terrorism and financial intelligence at the US treasury, said it was "extremely easy" for companies to register in Hong Kong, and authorities needed to tighten up.
But it has also earned a reputation for murky dealings -- the 2016 Panama Papers leak exposed the city as playing a key role in channelling money to tax havens via thousands of shell companies, including some linked to China's top political brass.
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Mandelker said that city authorities must "send a strong message that Hong Kong is not going to be a place where companies can find any kind of safe harbour" for front companies or shell companies.
City authorities had no immediate response today.
Mandelker also said her team had pressed Beijing to expel North Korean financial facilitators or bank representatives who "illicitly access the international financial system".
China is the North's biggest trading partner and has been accused by US President Donald Trump of helping Pyongyang skirt sanctions.
Last month it emerged that South Korea had briefly seized and inspected a Hong Kong-registered ship in November for transferring oil products to a North Korean vessel and breaching UN sanctions.
The firm that owned the ship had a registered office in Hong Kong and a director with an address in the southern mainland city of Guangzhou, according to Hong Kong's companies registry.
Hong Kong is part of China but is semi-autonomous with its own British-style independent legal system. Rule of law has been a major factor in wooing global business.
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