Myanmar's stunning transition from decades of repressive junta rule to a civilian-led government steered by Aung San Suu Kyi and her pro-democracy party was accompanied by the lifting of most Western embargoes.
The United States rolled back many of its sanctions to reward reforms since 2011, but kept a clutch of blacklists targeting junta-era cronies and their sprawling business interests as it seeks to push further changes.
"We recognise that even these limited, targeted sanctions occasionally have unintended effects on the broader economy," ambassador Scot Marciel said at a press conference in Yangon.
Washington is likely to maintain the backbone of its sanction powers in a nation where the military continues to wield huge political and economic power, despite Suu Kyi's November election win.
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Marciel said Washington would maintain focus on improving Myanmar's human rights situation, as well as amending the country's junta-drafted constitution, which ringfences the army's continued clout and bars Suu Kyi from becoming president.
In December the US temporarily eased restrictions on Myanmar's ports to unclog trade into the fast-developing country.
The move freed businesses to import and export through the main Yangon port terminal, which is run by Asia World, one of the country's largest blacklisted conglomerates.
Marciel declined to be drawn on recent reports that Suu Kyi, in her role as foreign minister, had indicated that the US should refrain from using the term "Rohingya" to apply to the persecuted Muslim minority in western Myanmar.
Marciel said that communities around the world "get to choose what they want to be called".
"That's a fundamental international practice and we respect that," Marciel said, without using the term Rohingya.
Suu Kyi has long faced criticism over her reticence to speak out more strongly in support of the Rohingya.