The suspicious vehicle was stopped in the western state of Apure, the National Anti-Drug Office (ONA) said.
"The drugs were being transported... By two people of Venezuelan nationality," ONA chief General Alejandro Keleris wrote on Twitter.
In 2012, about 45 tonnes of drugs were seized in Venezuela, according to official figures.
Drug traffickers -- including members of Mexico's powerful crime syndicates -- are increasingly using Venezuela to smuggle drugs into other nations.