Andhra's decision to bowl first after winning the toss boomeranged spectacularly as Karnataka posted 330 runs, riding on Agarwal's 137-ball 162 and Manish Pandey's 63-ball 75.
In reply, Andhra folded for 196 in 47.4 overs with Kaif's 54 and Siva Kumar's 40 being the only highlights of a disappointing batting performance.
Agarwal's brilliant knock was studded with 22 fours and three sixes before he ended up being caught by Ricky Bhui off Andhra's top wicket-taker Ayyappa Bandaru, who was their most economical as well picking up four for 43 in his 10 overs.
Abhimanyu Mithun was the wrecker-in-chief for Karnataka, bagging four for 18 in his stifling 10 overs. Udit Patel picked up three for 46 in his 10 overs as Karnataka grabbed a comfortable win.
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Brief Scores:
Karnataka: 330/6 in 50 overs (Mayank Agarwal 162, Manish Pandey 75, Ayyappa Bandaru 4/43).
Andhra Pradesh: 196 all out in 47.4 overs (Kaif 54, Siva Kumar 40, Abhimanyu Mithun 4/18).