The film was released this year and was a sequel to Ridley Scott's original movie starring Harrison Ford.
Ford reprised his role of Rick Deckard in the sequel, which also featured actor Ryan Gosling as Agent K.
Critics claimed that world in the film was hostile to women and criticised the representation of its female characters.
"I am very sensitive to how I portray women in movies. This is my ninth feature film and six of them have women in the lead role," he said in an interview to Vanity Fair.
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The "Arrival" director also said that cinema shows a mirror to the society and feels "Blade Runner 2049" was about the present and not the future.
"What is cinema? Cinema is a mirror on society. Blade Runner is not about tomorrow; it's about today. And I'm sorry, but the world is not kind on women," he said.
"There's a sense in American cinema: you want to portray an ideal world. You want to portray a utopia. That's good dreams for a better world, to advocate for something better, yes. But if you look at my movies, they are exploring today's shadows. The first Blade Runner is the biggest dystopian statement of the last half century. I did the follow-up to that, so yes, it's a dystopian vision of today. Which magnifies all the faults. That's what Ill say about that," he added.
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