It is the third major outbreak of unrest in different parts of Darfur, an area about the size of France, in the past several days.
The African Union-United Nations Mission in Darfur (UNAMID) said in a statement that thousands have been displaced from the town of Saraf Omra, about 100 kilometres east of El-Geneina, the capital of West Darfur state.
They have sought safety around a UNAMID base in the area.
"Patrols by the mission have observed looting around the town and the destruction of the local marketplace," after what it called "inter-communal" violence.
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Darfur has seen a surge in unrest, generally between Arab militias, over the past year.
"The incident in Saraf Omra comes in the wake of other recent episodes of violence in Darfur," UNAMID said, referring to unrest in the Taweisha and El Lait areas of North Darfur, and other violence in South Darfur.
Residents of the El Lait area last week reported a heavy presence of rebel troops from the Sudan Liberation Army's Minni Minnawi faction.
Almost two million people have already been displaced in Darfur, where an 11-year-old rebellion has been compounded by worsening inter-communal violence and criminality.