During his five-minute routine on the popular American talk show, Das took a jibe at Donald Trump, explaining how he is like an arranged marriage.
"We didn't vote for this guy, now we got to live with him... To you Americans, that's your president, to most Indians, that's a marriage," he said.
Taking to Twitter, the 37-year-old star shared his excitement with fans and posted a picture of him along with O'Brien.
"A short man meets an incredibly tall one! I'm on @TeamCoco tonight on TBS! Tune in at 11/10c! #CONAN," Das captioned the photo.
"So I met apu and chief wiggum and as we know, they are both one of the funniest men out there! @HankAzaria @TeamCoco," he wrote alongside his photo with the actor.