Sehwag, who had raced to 32 off 31 balls could only manage 44 off 81 balls as he was cleaned bowled by medium pacer Basant Mohanty (1/42).
Delhi scored 231 for six before declaring and setting an impossible target of 285. Odisha in the 14 overs of formality managed 37 runs.
For Delhi Vaibhav Rawal (51, 101 balls, 5x4) and wicketkeeper Rahul Yadav (50 not out, 122 balls, 6x4) made half centuries.
With these three points, Delhi are now on 12 points from five games and will have to atleast win a couple of outright games to qualify for the knock-out stages.
Odisha on the otherhand now have 10 points from five games.
Brief Scores: Delhi 442 & 231/6 dec (Vaibhav Rawal 51, Rahul Yadav 50). Odisha 379 & 37/0.