While Irrfan has been diagnosed with a severe case of jaundice, Deepika's back injury, which the actor suffered while filming "Padmaavat" has resurfaced, the director said in a Facebook post.
The shooting for the film was expected to start from next month in Nepal.
"I am pushing back the film by a few months as both of my lead actors are down with different health problems. Irrfan is down with jaundice and it will take him a few weeks to recover and Deepika Padukone's back problem which had previously developed during the shooting of Padmaavat has now resurfaced.
The director also clarified that the film is not based on underworld don Sapna Didi's life. He, however, asserted that her story was initially a reference point to the subject.
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Produced by Prernaa Arora's KriArj Entertainment, the movie is an adaptation of S Hussain Zaidi's book "Mafia Queens of Mumbai".
Earlier, the movie was said to be based on the life and times of Ashraf Khan, popularly known as Sapna Didi, who was a feared name in the underworld.
He added the look tests of the main leads have come out "exceptionally well".
"In the past few weeks, I felt like I was back in the days 'Maqbool' while prepping with them. Deepika and Irrfan's look tests have come out exceptionally well."
Deepika has previously worked with the actor in "Piku".