The tie-up will allow Vistara's customers to avail Avis car rental services, including both chauffeur-driven as well as self-driven cars, across 20 cities.
"Customers booked on a Vistara flight can opt for this service at the time of booking a ticket or later, through the 'Enhance My Booking' option on the airline's website," Vistara said in a statement.
Members of Vistara Club will also get reward points, the airline added.
Vistara operates a fleet of 16 Airbus A320 aircraft and provides services to 21 destinations.
Its Indian arm is a joint-venture between Avis Budget Group and Oberoi Group with presence in 20 locations including New Delhi, Mumbai, Chennai, Hyderabad, Kolkata, Bangalore, Agra, Ahmedabad, Shimla, Rishikesh and Udaipur.