While the Fed is not expected to announce any hike in rates tonight after its two-day policy meeting ends, markets are bracing for a hike that may be just a couple months away.
IMF chief Christine Lagarde has warned of a repeat of high market volatility and capital outflows when US Fed hikes rates next time and has asked India and other emerging markets to be prepared for such an eventuality.
Traders are keeping a close eye on what the US central bank has to say about its near-term plans after a recent mixed bag of economic data.
The Sensex dropped afterwards to 28,546.76 on fresh selling before concluding at 28,622.12, showing a loss of 114.26 points of 0.40 per cent. Yesterday, it had rallied nearly 299 points on speculation Fed wont's hike rates soon.
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"Participants' remained on sidelines ahead of the Fed outcome. Sentiments was dampened after IMF chief comments' on risks to market stability in emerging economies after a US rate hike," said Jayant Manglik, President-retail distribution, Religare Securities.
Other major losers which also pulled down the Sensex include NTPC, BHEL, Wipro, M&M, ONGC, Bharti Airtel, HDFC, ITC, Hindalco, HUL, L&T, Bajaj Auto and Infosys.
The CNX 50-share Nifty also declined by 37.40 points, or 0.43 per cent, to finish at 8,685.90 today.
Globally, most Asian bourses closed up on hopes of further measures to stimulate the Chinese economy. Europe opened better ahead of British government's annual budget and the US Federal Reserve policy decision.