At stake are all the 435 seats in the House of Representatives, 36 of the 100 Senate Seats and gubernatorial elections in 36 of the 50 States.
These States are also having elections for the state assembly and city councils, like that of Washington DC.
The Republicans, who already control the House of Representatives, need to gain just six seats to take the Senate.
Mid-term elections have national consequences and the results will determine what Obama can get done in his final two years in office. A hostile Congress might increase Obama's worries as he contends with global issues like Ebola and advancing Islamic State militants in Iraq and Syria, while struggling to show dramatic upswing in the economy.
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Topping the list is Nikki Haley for Governor of South Carolina and Ami Bera for House of Representatives in California - both of whom are seeking their re-election.
Young Ro Khanna, who is challenging his own Democratic leader Mike Honda, has also caught the attention of Indian- Americans. The community is also looking at the election of Tulsi Gabbard, the first Hindu lawmaker, who is seeking re-election from Hawaii.
Latest opinion polls show that people are disappointed with the Obama Administration.
Perhaps for the first time, candidates also held special meetings for the Indian-American community, recognizing their growing political clout in the country.
For instance, Senator Mark Warner from Virginia, not only attended a number of Indian-American community events in Virginia but also held conference calls urging them to vote for them.