"I guess my greatest regret was voting to give (the then) President (George) Bush authority in Iraq," Clinton told Good Morning America of the ABC News in an interview.
"It did not turn out the way that I had thought it would, based on what he had said. I regret that and I've said that it was a mistake and, obviously, it's something that, you know, I wish hadn't turned out the way it did," Clinton said.
During the interview, Clinton said women are still not being treated fairly when it comes to their salaries.
"It's 2016 and we're still facing the reality that women are not paid equally to men," she said.
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"This is not just a woman's issue. This is a family issue and an economic issue. If you have a mother, a wife, a daughter, a sister, you are being cheated, because if you don't get equal pay, then that affects your whole family income," she said and promised to change it if voted to power.
Clinton said she is not a natural politician.
"I know I'm not a natural politician and I know that it sometimes is more difficult to navigate through the politics and the campaigning than I wish it were," she said.
"But when I have a job, like being senator from New York, being secretary of state, people really count on me and I do my very best to deliver for them. I ran that hard campaign against Senator Obama. We finished. He turned around. He trusted me enough to be his secretary of state," she asserted.